Social attention: a possible early indicator of efficacy in autism clinical trials
1 Autism Speaks, New York, NY, USA
2 Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-3366, USA
3 Department of Psychology, University of Washington, Seattle, WA 98195, USA
4 Department of Psychiatry, University of Washington, Seattle, WA 98195, USA
5 Department of Pharmacology and Physiology, Drexel University School of Medicine, Philadelphia, PA 19102, USA
Journal of Neurodevelopmental Disorders 2012, 4:11 doi:10.1186/1866-1955-4-11Published: 17 May 2012
For decades, researchers have sought to clarify the nature of the social communication impairments in autism, highlighting impaired or atypical 'social attention' as a key measurable construct that helps to define the core impairment of social communication. In this paper, we provide an overview of research on social attention impairments in autism and their relation to deficiencies in neural circuitry related to social reward. We offer a framework for considering social attention as a potential moderator or mediator of response to early behavioral intervention, and as an early indicator of efficacy of behavioral and/or pharmacological treatments aimed at addressing the social impairments in autism.